Amino acid Transporter

氨基酸转运蛋白

Amino acid transporters are a class of membrane proteins responsible for transporting amino acids between the inside and outside of cells, crucial for maintaining the balance of amino acid concentrations. The SLC3 and SLC7 families are two well-studied classes of amino acid transporters. The SLC7 family includes cationic amino acid transporters (CATs) and L-type amino acid transporters (LATs), with LATs typically forming heterodimeric complexes with the heavy chain subunits of the SLC3 family through disulfide bonds, known as heteromeric amino acid transporters (HATs).
Amino acid transporters are involved in regulating intracellular signaling pathways such as the mammalian target of rapamycin complex 1 (mTORC1) and the general control non-derepressible (GCN) pathways, influencing protein synthesis, cell proliferation, and growth through the regulation of these signaling pathways. Dysfunctions in amino acid transporters are associated with diseases such as hereditary aminoaciduria, tumor growth, and absorption disorders in the intestines and kidneys. Specific transporters, like LAT1 and SLC7A5, play crucial roles in the proliferation and metabolism of tumor cells and can serve as potential drug targets^[1]^[2].

References:

[1]. Fotiadis D, et al. The SLC3 and SLC7 families of amino acid transporters. Mol Aspects Med. 2013 Apr-Jun;34(2-3):139-58. [Content Brief]

[2]. Taylor PM. Role of amino acid transporters in amino acid sensing. Am J Clin Nutr. 2014 Jan;99(1):223S-230S. [Content Brief]

Amino acid Transporter Related Products (23):

By Effects:	Inhibitors (15) Substrate (1) Activator (1)

Cat. No.	Product Name	Effect	Purity	Chemical Structure

HY-134452

MeAIB		99.96%
MeAIB (α-(Methylamino)isobutyric acid) is a specific?substrate for amino acid transport system A (ATA1). ATA mediate the uptake of short-chain neutral amino acids in a Na⁺-dependent manner.

HY-120139

KMH-233	Inhibitor	99.75%
KMH-233, a potent, reversible and selective inhibitor of l-type amino acid transporter LAT1/SLC7A5, inhibits the uptake of LAT1 substrate, l-leucin (IC₅₀=18 μM) as well as cell growth. KMH-233 significantly potentiates the efficacy of Bestatin and Cisplatin even at low concentrations (25 μM).

HY-W402682

SXC2023	Activator	99.85%
SXC-2023 is an orally active cystine-glutamate antiporter (SLC7A11; System xc-) activator. SXC-2023 can be used for the study of central nervous system disorders, such as trichotillomania.

HY-156682

JNT-517	Inhibitor	99.00%
JNT-517 is an orally active, selective SLC6A19 allosteric inhibitor with an IC₅₀ of 47 nM for human SLC6A19. JNT-517 can be used for the study of phenylketonuria (PKU).

HY-B1274

Cinromide	Inhibitor	99.83%
Cinromide is an anticonvulsant agent. Cinromide inhibits epithelial neutral amino acid transporter B⁰AT1 (SLC6A19) with an IC₅₀ of 0.5 μM.

HY-179581

SLC6A19-IN-4	Inhibitor	99.55%
SLC6A19-IN-4 is an allosteric-competitive and orally active B⁰AT1 inhibitor. SLC6A19-IN-4 inhibits both human and mouse B⁰AT1 with IC₅₀ values of 513 nM and 295 nM, respectively. SLC6A19-IN-4 exhibits excellent metabolic stability. SLC6A19-IN-4 significantly increases urinary phenylalanine (Phe) excretion and reduces plasma Phe levels through dual inhibition of B⁰AT1 in both the intestine (reducing absorption) and kidney (promoting excretion) in vivo. SLC6A19-IN-4 can be used for phenylketonuria (PKU) and other disorders involving SLC6-family transporters research.

HY-14889

Fluciclovine
Fluciclovine is an amino acid analogue that can enter cells by targeting the amino acid transporters on the cell surface (mainly ASCT2 and LAT1). After being labeled with ¹⁸F, ¹⁸F-fluciclovine can be used as an imaging agent for positron emission tomography (PET) for prostate diagnosis imaging.

HY-181743

Piezo1 agonist 2
Piezo1 agonist 2 (Compound PD2) is a blood-brain barrier-permeable Piezo1 agonist and Jedi2 (HY-131018) conjugate that utilizes LAT1. Piezo1 agonist 2 releases Jedi2 in mice. Piezo1 agonist 2 can be used for the research of neurodegenerative diseases.

HY-161137

LQFM215	Inhibitor	99.80%
LQFM215 is a proline transporter (PROT) inhibitor. LQFM215 inhibits proline transport by competitively binding to the active site of PROT. LQFM215 effectively reduces hyperlocomotion and enhances social interaction.

HY-162864

JX237	Inhibitor	98.84%
JX237 is an inhibitor of the epithelial neutral amino acid transporter B⁰AT1 (SLC6A19) with an IC₅₀ value of 31 nM. SLC6A19 is the main transporter for the absorption of neutral amino acids in the intestines and their reabsorption in the kidneys. By inhibiting B⁰AT1, JX237 can be used for the study of disorders of amino acid metabolism.

HY-115704

Butyryl-L-carnitine chloride		99.55%
Butyryl-L-carnitine chloride is an acylcarnitine that can be isolated from Plasma/Serum.

HY-153763

PROT-IN-1	Inhibitor	98.0%
PROT-IN-1 (Compound 2) is a proline transporter (PROT) inhibitor (IC₅₀: 1.48 μM). PROT-IN-1 can be used for research of cognitive disorders.

HY-176719

AKR1B1/STAT3/SLC7A11-regulator-1	Inhibitor
AKR1B1/STAT3/SLC7A11-regulator-1 (5a) is an AKR1B1/STAT3/SLC7A11 regulator that reverses DOX resistance in MCF-7/ADR cells by enhancing ferroptosis activity. AKR1B1/STAT3/SLC7A11-regulator-1 can be used in breast cancer research.

HY-183147A

LAT1-IN-2 hydrochloride	Substrate
LAT1-IN-2 hydrochloride is an orally active anticancer agent, as well as a LAT1 substrate and tubulin-binding agent. LAT1-IN-2 hydrochloride relies on LAT1 for cellular uptake, disrupts microtubule formation by binding to the colchicine site of tubulin, and induces actin depolymerization to transform cells into a spherical shape. LAT1-IN-2 hydrochloride effectively inhibits tumor growth in xenograft mice. Compared with Etoposide (HY-13629), LAT1-IN-2 hydrochloride shows higher distribution in tumor tissues, lower distribution in major organs, and better tolerability. LAT1-IN-2 hydrochloride has been applied in studies related to esophageal cancer.

HY-179107

SLC6A19-IN-3	Inhibitor
SLC6A19-IN-3 (Compound 83-P1-P2) is a potent, selective and orally active SLC6A19 inhibitor with an IC₅₀ of 28 nM. SLC6A19-IN-3 can block SLC6A19-mediated transmembrane transport of phenylalanine, reducing intestinal absorption of phenylalanine from food and renal tubular reabsorption of phenylalanine. SLC6A19-IN-3 can be used for the research of metabolic disease, such as phenylketonuria.

HY-158161

SLC6A19-IN-1	Inhibitor
SLC6A19-IN-1 is a potent and highly selective inhibitor and transport corrector of human SLC6A19 (IC₅₀=47 nM). Furthermore, at a concentration of 35 μM, SLC6A19-IN-1 exhibits no activity against SLC1A5, SLC7A5, or SLC6A8. SLC6A19-IN-1 is applicable to research on phenylketonuria (PKU) and hyperphenylalaninemia. SLC6A19-IN-1 is also suitable for studies related to various metabolic disorders, including tyrosinemia, maple syrup urine disease, urea cycle disorders, and hyperammonemia.

HY-117251

LP-403812	Inhibitor
LP-403812 is a high affinity proline transporter (PROT) inhibitor that produces dose-dependent inhibition of hPROT (IC₅₀=0.11 μM; K_i=0.12 μM) and also inhibits the activity of mouse brain synaptosomal mPROT with the same potency (IC₅₀=0.23 μM). LP-403812 can be used to study the function of PROT in the brain.

HY-W695425

Creatine transporter-IN-1	Inhibitor
Creatine transporter-IN-1 is a synthetic creatine transporter (CT1/SLC6A8) inhibitor. Creatine transporter-IN-1 inhibits creatine uptake and shows anticancer activity against cancer cells.

HY-181753

INSP-0154
INSP-0154 is a potent creatine kinase B (CKB)/creatine transporter (SLC6A8) inhibitor. INSP-0154 binds to the SLC6A8 occluded pocket, prevents creatine transport into cells, and protects SLC6A8 cysteine residue C144 from irreversible inactivation. INSP-0154 inhibits creatine uptake in mouse heart tissue. INSP-0154 can be used for the research of cancer.

HY-113745

LX-6171	Inhibitor
LX-6171 is an orally active SLC6A7 inhibitor. LX-6171 can be used to study diseases characterized by cognitive impairment, such as Alzheimer's disease, schizophrenia or vascular dementia.

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